Repeatability of Motion Health Screening Scores Acquired from a Three-Dimensional Markerless Motion Capture System

The purpose of the present study was to examine the repeatability of five algorithm-derived motion health screening scores (i.e., readiness, explosiveness, functionality, quality, and dysfunction) obtained from an innovative three-dimensional markerless motion capture system, composed of eight high-definition cameras recording at 60 fps. Thirteen females and six males performed two sets of three motion capture screenings, separated one week apart (six in total). The screenings consisted of 20 body movements performed in sequential order. Each screening within a testing session was separated by a 30 min rest interval to avoid the possible influence of fatigue. A trained research team member, facing the participant and standing outside of the camera capture range, was present to demonstrate each individual movement. The order in which motions were performed was identical across all participants. Repeated measures analysis of variance and intraclass correlation coefficients were used to examine statistically significant differences and measurement agreement across six testing sessions. The findings of the present study revealed no significant differences in algorithm-based motion health screening scores across multiple testing sessions. Moreover, excellent measurement reliability was found for readiness scores (ICC, 95% CI; 0.957, 0.914–0.980), good-to-excellent for functionality (0.905, 0.821–0.959) and explosiveness scores (0.906, 0.822–0.959), and moderate-to-excellent for dysfunction (0.829, 0.675–0.925) and quality scores (0.808, 0.635–0.915)

Impact of Distance and Proficiency on Shooting Kinematics in Professional Male Basketball Players

Shooting efficiency is one of the key performance parameters related to securing the desired game outcome at various levels of basketball competition, and it is largely influenced by the biomechanical adjustments incorporated during the preparatory and release phase of the shooting motion. Thus, the purpose of the present study was twofold: (a) to examine the differences in the kinematic characteristics between free-throw, two-point, and three-point shots, and (b) to examine the differences between shooters with excellent (≥80%) and good (<80%) levels of shooting proficiency. A total of 10 professional male basketball players performed 5 free-throw (4.57 m), two-point (5.18 m), and three-point (6.75 m) shots, combining for a total of 150 shots. A high-definition camera recording at 120 fps was used to capture the shooting motion from a sagittal point of view, and video analysis software was used to analyze the kinematic variables of interest. The findings of the present study reveal that the kinematic characteristics during the preparatory phase of the shooting motion remain unchanged between free-throw and two-point shots. Three-point shots required lower elbow positioning, influenced by greater knee and hip flexion when compared to free-throw and two-point shots. The release angle was notably lower for shots attempted beyond the three-point line but remained unchanged between the free-throw and two-point shooting motions. Release height and vertical displacement were significantly greater for two- and three-point shots when compared to free-throw shots, while no difference was observed between the two- and three-point shots. In addition, no significant differences in shooting kinematics were observed between those participants with excellent and good levels of shooting proficiency

Relationship between Upper and Lower Body Strength and Basketball Shooting Performance

Strength is one of the key physiological performance attributes related to optimal on-court basketball performance. However, there is a lack of scientific literature studying how strength relates to shooting proficiency, as a key basketball skill capable of discriminating winning from losing game outcomes. Thus, the purpose of the present study was to examine the relationship between maximal upper and lower body strength and free-throw, two-point, and three-point shooting accuracy. Ten males and seven females performed bench press and back squat one repetition maximum (1RM) and basketball shooting testing during two laboratory visits. The shooting protocol consisted of five sets of 15 free-throw, two-point, and three-point shots performed in sequential order. Each set was separated by a 30 min rest interval to minimize the influence of fatigue. Each subject attempted 225 shots, combining for a total of 3825 shots. The average free-throw, two-point, and three-point shooting accuracy for men were 74.5 ± 11.9, 68.4 ± 9.9, and 53.3 ± 14.9%, and for women 79.2 ± 11.2, 65.5 ± 8.4, and 51.2 ± 15.3%, respectively. The average bench press and back squat 1RM for men was 88.2 ± 18.6 and 117.0 ± 21.2 kg, and for women, 40.6 ± 7.5 and 66.9 ± 9.9 kg, respectively. The findings of the present study revealed no significant relationships between maximal upper and lower body strength and basketball shooting performance for both male and female participants. Neither bench press nor back squat 1RM was a good predictor of free-throw, two-point, and three-point shooting performance

Inference of Relationships in Population Data Using Identity-by-Descent and Identity-by-State

It is an assumption of large, population-based datasets that samples are annotated accurately whether they correspond to known relationships or unrelated individuals. These annotations are key for a broad range of genetics applications. While many methods are available to assess relatedness that involve estimates of identity-by-descent (IBD) and/or identity-by-state (IBS) allele-sharing proportions, we developed a novel approach that estimates IBD0, 1, and 2 based on observed IBS within windows. When combined with genome-wide IBS information, it provides an intuitive and practical graphical approach with the capacity to analyze datasets with thousands of samples without prior information about relatedness between individuals or haplotypes. We applied the method to a commonly used Human Variation Panel consisting of 400 nominally unrelated individuals. Surprisingly, we identified identical, parent-child, and full-sibling relationships and reconstructed pedigrees. In two instances non-sibling pairs of individuals in these pedigrees had unexpected IBD2 levels, as well as multiple regions of homozygosity, implying inbreeding. This combined method allowed us to distinguish related individuals from those having atypical heterozygosity rates and determine which individuals were outliers with respect to their designated population. Additionally, it becomes increasingly difficult to identify distant relatedness using genome-wide IBS methods alone. However, our IBD method further identified distant relatedness between individuals within populations, supported by the presence of megabase-scale regions lacking IBS0 across individual chromosomes. We benchmarked our approach against the hidden Markov model of a leading software package (PLINK), showing improved calling of distantly related individuals, and we validated it using a known pedigree from a clinical study. The application of this approach could improve genome-wide association, linkage, heterozygosity, and other population genomics studies that rely on SNP genotype data

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Kinetic and Kinematic Characteristics of Setting Motions in Female Volleyball Players

While being an integral part of both the offensive and defensive segments of the game, the biomechanical parameters of setting motions remain understudied in the scientific literature. Thus, the purpose of the present study was to examine differences in kinetic and kinematic characteristics between: (a) three types of setting motions (i.e., front, middle, back); (b) two types of setting approaches (i.e., stationary, step-in); and (c) proficient (PRO) and non-proficient (N-PRO) volleyball players. Twenty recreationally active females performed five stationary and five step-in setting approaches to Zone 4–2 in a randomized order. Uni-dimensional force plate sampling at 1000 Hz and high-definition camera recording at 30 fps were used to obtain kinetic and kinematic variables of interest. The total number of setting attempts performed by each subject was 30, accounting for a grand total of 600 attempts. PRO setters had less knee flexion, shoulder flexion, and ankle dorsiflexion at the initial concentric phase of the volleyball setting motion when compared to the N-PRO setters. Moreover, significantly greater peak concentric and landing forces, impulse, rate of force development, and vertical jump height were observed for PRO setters compared to N-PRO setters, while no significant differences were found between different setting targets and approaches

Kinetic and Kinematic Characteristics of Setting Motions in Female Volleyball Players

While being an integral part of both the offensive and defensive segments of the game, the biomechanical parameters of setting motions remain understudied in the scientific literature. Thus, the purpose of the present study was to examine differences in kinetic and kinematic characteristics between: (a) three types of setting motions (i.e., front, middle, back); (b) two types of setting approaches (i.e., stationary, step-in); and (c) proficient (PRO) and non-proficient (N-PRO) volleyball players. Twenty recreationally active females performed five stationary and five step-in setting approaches to Zone 4&ndash;2 in a randomized order. Uni-dimensional force plate sampling at 1000 Hz and high-definition camera recording at 30 fps were used to obtain kinetic and kinematic variables of interest. The total number of setting attempts performed by each subject was 30, accounting for a grand total of 600 attempts. PRO setters had less knee flexion, shoulder flexion, and ankle dorsiflexion at the initial concentric phase of the volleyball setting motion when compared to the N-PRO setters. Moreover, significantly greater peak concentric and landing forces, impulse, rate of force development, and vertical jump height were observed for PRO setters compared to N-PRO setters, while no significant differences were found between different setting targets and approaches

Relationship between Upper and Lower Body Strength and Basketball Shooting Performance

Strength is one of the key physiological performance attributes related to optimal on-court basketball performance. However, there is a lack of scientific literature studying how strength relates to shooting proficiency, as a key basketball skill capable of discriminating winning from losing game outcomes. Thus, the purpose of the present study was to examine the relationship between maximal upper and lower body strength and free-throw, two-point, and three-point shooting accuracy. Ten males and seven females performed bench press and back squat one repetition maximum (1RM) and basketball shooting testing during two laboratory visits. The shooting protocol consisted of five sets of 15 free-throw, two-point, and three-point shots performed in sequential order. Each set was separated by a 30 min rest interval to minimize the influence of fatigue. Each subject attempted 225 shots, combining for a total of 3825 shots. The average free-throw, two-point, and three-point shooting accuracy for men were 74.5 &plusmn; 11.9, 68.4 &plusmn; 9.9, and 53.3 &plusmn; 14.9%, and for women 79.2 &plusmn; 11.2, 65.5 &plusmn; 8.4, and 51.2 &plusmn; 15.3%, respectively. The average bench press and back squat 1RM for men was 88.2 &plusmn; 18.6 and 117.0 &plusmn; 21.2 kg, and for women, 40.6 &plusmn; 7.5 and 66.9 &plusmn; 9.9 kg, respectively. The findings of the present study revealed no significant relationships between maximal upper and lower body strength and basketball shooting performance for both male and female participants. Neither bench press nor back squat 1RM was a good predictor of free-throw, two-point, and three-point shooting performance